Kill the God of Destruction:
To kill the God Of Destruction easily, get the Doppleganger card. Toss it near him and it may kill him with one hit.
However, the Doppleganger card is difficult to get. You will need to upgrade the following cards to 9,999 EXP Points:
#45-Great Turtle
#69-Blue Dragon
#83-White Tiger*
#104-God Of Destruction* * Note: You will want to copy these cards prior to transforming because they are rare cards.
